• Academic Staff

      Professor Kansu Büyükafşar
    Profile
    :
    Department
    :
    Faculty of Medicine/Department of Medical Pharmacology .
    Business Address
    :
    Tıbbi Farmakoloji Ad., Tıp Fakültesi, Mersin Üniversitesi, Çiftlikköy Kampüsü 33343 Yenişehir/ Mersin .
    Phone
    :
    +90 -324-3610684 .
    Internal
    :
    29118 .
    Fax
    :
    +90 -- .
    Alternative e-mail
    :
    Alternative e-mail
    :
    URL
    :
    VCARD
    :
    Created
    :
    2015-09-14 12:41:44 .
    Last Modification
    :
    2024-02-27 12:42:19 .
    Researcher ID :
    A-4885-2016
    Scopus ID :
    Orcid ID :
    0000-0003-4117-6013
    Scholar ID :
    h-index :
    20
    Publons ID :
    A-4885-2016
    Point :
    51620

    Degree Department/Program Institute Year
    PHARMACY EGE UNIVERSITY 1990
    1994
    1996
    2000

    Doctorate Thesis

    1. Effects of nitric oxide on the proliferation, differentiation and acytoskeleton actin organisation in preadipocytes (3T3-L1): Possible role of Rho/Rho-kinase pathway, Supervisor: Dr. Kansu BÜYÜKAFŞAR, Mersin University, Graduate School of Health Sciences, Pharmacology Department, Mersin, Turkey, Continue.

    2. The role of G protein-coupled estrogen receptor on the control of rat renal perfusion pressure, Supervisor: Dr. Kansu BÜYÜKAFŞAR, Mersin University, Graduate School of Health Sciences, Pharmacology Department, Mersin, Turkey, .

    3. Functional significance of Rho/Rho-kinase signalling mechanism in the human erythrocytes, Supervisor: Dr. Kansu BÜYÜKAFŞAR, Mersin University, Graduate School of Health Sciences, Pharmacology Department, Mersin, Turkey, .

    Expertise in Medicine Thesis

    1. Rho/Rho-kinase pathway in the brain, corpus cavernosum and aorta of alcholic mice, Supervisor: Dr. Kansu BÜYÜKAFŞAR, Mersin University, Graduate School of Health Sciences, Pharmacology Department, Mersin, Turkey, Continue.

    2. Investigation of Rho/Rho-kinase signalling in the diabetic mouse aorta, corpus cavernosum and gastric fundus, Supervisor: Dr. Kansu BÜYÜKAFŞAR, Mersin University, Graduate School of Health Sciences, Pharmacology Department, Mersin, Turkey, .

    3. Effects of estrogen and progesteron on adipocytokine release and differentiation in preadipocytes (3T3-L1): Possible contribution of Rho/Rho-kinase pathway, Supervisor: Dr. Kansu BÜYÜKAFŞAR, Mersin University, Graduate School of Health Sciences, Pharmacology Department, Mersin, Turkey, .

    Master Thesis

    1. Possible Regenerative Effect of Bone Marrow Mesenchymal Stem Cell-Derived Exosomes in Oleic Acid-Induced Lung Injury in Rats, Supervisor: Dr. Kansu Büyükafşar, Mersin University, Graduate School of Health Sciences, Other Department, Mersin, Turkey, Continue.

    Theses_001.pdf

    2. Expression of Rho-kinase and effects of its inhibitors in the rat mesenteric artery, Supervisor: Dr. Kansu BÜYÜKAFŞAR, Mersin University, Graduate School of Health Sciences, Pharmacology Department, Mersin, Turkey, Continue.

    3. Nature of ultraviolet light-induced relaxation in the rabbit corpus cavernosum, Supervisor: Dr. Kansu BÜYÜKAFŞAR, Mersin University, Graduate School of Health Sciences, Pharmacology Department, Mersin, Turkey, .

    4. Effects of cytidine 5' triphosphate on urogenital, gastrointestinal and respiratory smooth muscle, Supervisor: Dr. Kansu BÜYÜKAFŞAR, Others, Others, Other Department, Mersin, Turkey, .

    5. Relation between nitric oxide (NO) and Rho/Rho-kinase in coronary microvascular endothelial cell culture, Supervisor: Dr. Kansu BÜYÜKAFŞAR, Mersin University, Graduate School of Health Sciences, Pharmacology Department, Mersin, Turkey, .

    6. Effects of ex hormones on Rho/Rho-kinase pathway in coronary endothelial cell culture, Supervisor: Dr. Kansu BÜYÜKAFŞAR, Mersin University, Graduate School of Health Sciences, Pharmacology Department, Mersin, Turkey, .

    Title Institute Year
    PROF. DR. NEAR EAST UNIVERSITY 2013-09-17 - 2018-09-08
    PROF. DR. MERSIN UNIVERSITY 1999-03-26 - Continue
    PROF. DR. GIRNE AMERICAN UNIVERSITY 2022-06-27 - Continue

    Title Dutie Institution/Other Year
    HEAD OF DEPARTMENT INSTITUTE OF HEATH SCIENCE DEPARTMENT OF STEM CELL AND REGENERATIVE MEDICINE 2019-10-03 - Continue
    HEAD OF DEPARTMENT FACULTY OF MEDICINE DEPARTMENT OF MEDICAL PHARMACOLOGY 1999-03-26 - Continue
    BOARD MEMBER INSTITUTE OF HEATH SCIENCE DEPARTMENT OF MEDICAL PHARMACOLOGY 1999-03-26 - Continue
    2021-07-09 - 2023-07-09
    2020-07-09 - 2023-07-09
    2020-07-09 - 2023-07-09
    2020-07-09 - 2023-07-09
    2020-07-09 - 2023-07-09
    2020-07-09 - 2023-07-09
    2020-07-09 - 2023-07-09
    2020-07-09 - 2023-07-09
    2019-10-03 - 2022-10-03
    2019-10-03 - 2022-10-03
    2019-10-03 - 2022-10-03
    2019-10-03 - 2022-10-03
    2019-10-03 - 2022-10-03
    2019-10-03 - 2022-10-03
    2019-07-09 - 2021-07-09
    2019-07-09 - 2021-07-09
    2017-07-08 - 2020-07-08
    2017-07-08 - 2020-07-08
    2008-02-29 - 2011-02-28

    International - SCI/SCI-Expanded category 37900
    2021
    59. İLHAN, E.; BÜYÜKAFŞAR, K.; TİFTİK, R.; SEÇİLMİŞ, M.; ALZAYED, Z. . BALKAN MEDICAL JOURNAL, 2021, 38, 304-309. 800 + 0
    10.5152/balkanmedj.2021.20014

    58. BÜYÜKAFŞAR, K.; GÖRÜR, K.; ÖZCAN, C.; İSMİ, O. . THE JOURNAL OF INTERNATIONAL ADVANCED OTOLOGY, 2021, 17, -. 950 + 0
    10.5152/iao.2021.21132

    57. SAYLAM, B.; EFESOY, O.; BOZDOĞAN ARPACI, R.; TİFTİK, R.; TEK, M.; BÜYÜKAFŞAR, K.; BOZLU, M.; ÇAYAN, S. . TURKISH JOURNAL OF MEDICAL SCIENCES, 2021, 49, 1491-1499. 250 + 0
    10.3906/sag-2004-15

    2019
    56. TİFTİK, R.; ÜN, İ.; YETKİN, D.; BÜYÜKAFŞAR, K. . UHOD-ULUSLARARASI HEMATOLOJI-ONKOLOJI DERGISI, 2019, , -. 650 + 0
    2018
    55. Çarçak, N.; Yavuz, M.; Eryiğit Karamahmutoğlu, T.; Kurt, A.; Urhan Küçük, M.; Onat, F.; Büyükafsar, K. Suppressive effect of Rho-kinase inhibitors Y-27632 and fasudil on spike-and-wave discharges in genetic absence epilepsy rats from Strasbourg (GAERS). SPRINGER NATURE AMERICA, INC, 2018, 391, 1275-1283. 200 + 0
    http://dx.doi.org/10.1007/s00210-018-1546-9

    54. ÇARÇAK YILMAZ, N.; Melis, Y.; KARAMAHMUTOĞLU, T.; KURT, A.; URHAN KÜÇÜK, M.; ONAT, F.; BÜYÜKAFŞAR, K. . NAUNYN-SCHMIEDEBERG’XXS ARCHIVES OF PHARMACOLOGY, 2018, 391, 1275-1283. 200 + 0
    10.1007/s00210-018-1546-9

    53. Sahin, L.; Cevik, O.; Koyuncu, D.; Buyukafsar, K. Role of rho-kinase (ROCK) in tonic but not phasic contraction in the frog stomach smooth muscle. ELSEVIER BV, 2018, 198, 46-55. 650 + 0
    http://dx.doi.org/10.1016/j.lfs.2018.02.023

    52. ŞAHİN, L.; ÇEVİK, Ö.; KOYUNCU, D.; BÜYÜKAFŞAR, K. . LIFE SCIENCES, 2018, 198, 46-55. 650 + 0
    10.1016/j.lfs.2018.02.023

    51. ÇARÇAK YILMAZ, N.; Yavuz, M.; KARAMAHMUTOĞLU, T.; KURT, A.; URHAN KÜÇÜK, M.; ONAT, F.; BÜYÜKAFŞAR, K. . NAUNYN-SCHMIEDEBERG’XXS ARCHIVES OF PHARMACOLOGY, 2018, 391, 1275-1283. 200 + 0
    10.1007/s00210-018-1546-9

    2017
    50. Yeşilova, M.; Görür, K.; Ismi, O.; Özcan, C.; Büyükafşar, K. The Role of Rho/Rho-Kinase Pathway in the Pathogenesis of Cholesteatoma. OVID TECHNOLOGIES (WOLTERS KLUWER HEALTH), 2017, 38, 516-520. 500 + 0
    http://dx.doi.org/10.1097/MAO.0000000000001344

    49. Kubat, H.; Yurtsever, A.; Büyükafşar, K. Rho/rho-kinase signalling in chronically alcohol-fed mice. TURKISH JOURNAL OF MEDICAL SCIENCES, 2017, 47, 668-674. 1000 + 0
    10.3906/sag-1512-161

    2015
    48. Kurt, A.; Macit, E.; Uzbay, T.; Buyukafsar, K. Effects of ethanol withdrawal on the activity of rho-kinase in rat brain. BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY, 2015, 116, 490-493. 650 + 0
    https://dx.doi.org/10.4149/BLL_2015_093

    47. Pektas, M.; Kurt, A.; Un, I.; Tiftik, R.; Buyukafsar, K. Effects of 17 beta-estradiol and progesterone on the production of adipokines in differentiating 3T3-L1 adipocytes: Role of Rho-kinase. CYTOKINE, 2015, 72, 130-134. 500 + 10
    https://dx.doi.org/10.1016/j.cyto.2014.12.020


    Times Cited: 2
    2014
    46. Secilmis, M.; Ozu, O.; Kiroglu, O.; Singirik, E.; Buyukafsar, K. The production of vasoconstriction-induced residual NO modulates perfusion pressure in rat mesenteric vascular bed. PERFUSION-UK, 2014, 29, 488-495. 500 + 0
    https://dx.doi.org/10.1177/0267659114524263

    45. Tiftik, R.; Baskurt, O.; Kul, S.; Buyukafsar, K. The Functional Significance of the Rho/Rho-Kinase Pathway in Human Erythrocytes. TURKISH JOURNAL OF HEMATOLOGY, 2014, 31, 168-174. 650 + 0
    https://dx.doi.org/10.4274/tjh.2013.0115

    44. Cayan, S.; Saylam, B.; Tiftik, N.; Unal, N.; Apa, D.; Efesoy, O.; Cimen, B.; Bozlu, M.; Akbay, E.; Buyukafsar, K. Rho-kinase Levels in Testicular Ischemia-reperfusion Injury and Effects of Its Inhibitor, Y-27632, on Oxidative Stress, Spermatogenesis, and Apoptosis. UROLOGY, 2014, 83, 0-0. 100 + 5
    https://dx.doi.org/10.1016/j.urology.2013.11.032


    Times Cited: 1
    2013
    43. Kurt, A.; Buyukafsar, K. Vasoconstriction induced by G1, a G-protein-coupled oestrogen receptor1 (GPER-1) agonist, in the isolated perfused rat kidney. EUROPEAN JOURNAL OF PHARMACOLOGY, 2013, 702, 71-78. 1000 + 30
    https://dx.doi.org/10.1016/j.ejphar.2013.01.020


    Times Cited: 6
    42. Un, I.; Kurt, A.; Batus, A.; Buyukafsar, K. Alfacalcidol suppresses alpha-receptor-mediated vasoconstriction via an endothelium dependent mechanism. TURKISH JOURNAL OF MEDICAL SCIENCES, 2013, 43, 238-244. 650 + 0
    https://dx.doi.org/10.3906/sag-1205-92

    41. Un, I.; Kurt, A.; Buyukafsar, K. Hyperosmolar glucose induces vasoconstriction through Rho/Rho-kinase pathway in the rat aorta. FUNDAMENTAL & CLINICAL PHARMACOLOGY, 2013, 27, 244-251. 1000 + 5
    https://dx.doi.org/10.1111/j.1472-8206.2011.01014.x


    Times Cited: 1
    2011
    40. Yurtsever, A.; Pektas, M.; Ozkur, M.; Un, I.; Erenmemisoglu, A.; Buyukafsar, K. Proton pump inhibitors omeprazole, lansoprazole and pantoprazole induce relaxation in the rat lower oesophageal sphincter. JOURNAL OF PHARMACY AND PHARMACOLOGY, 2011, 63, 1295-1300. 400 + 25
    https://dx.doi.org/10.1111/j.2042-7158.2011.01333.x


    Times Cited: 5
    39. Guldali, O.; Savci, V.; Buyukafsar, K. CDP-choline-induced contractions in the mouse gastric fundus through purinoceptors and Rho/Rho-kinase signalling. LIFE SCIENCES, 2011, 88, 473-479. 1000 + 5
    https://dx.doi.org/10.1016/j.lfs.2011.01.002


    Times Cited: 1
    2008
    38. İnan, S.; Büyükafşar, K. Antiepileptic effects of two Rho-kinase inhibitors, Y-27632 and fasudil, in mice. WILEY-BLACKWELL, 2008, 155, 44-51. 1000 + 0
    http://dx.doi.org/10.1038/bjp.2008.225

    Publications_001.pdf

    37. Baumhaekel, M.; Schlimmer, N.; Buyukafsar, K.; Arikan, O.; Boehm, M. Nebivolol, but not metoprolol, improves endothelial function of the corpus cavernosum in apolipoprotein E-knockout mice. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2008, 325, 818-823. 700 + 120
    https://dx.doi.org/10.1124/jpet.107.135681


    Times Cited: 24
    36. ONUR, A.; BÜYÜKAFŞAR, K. . JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2008, 325, 818-823. 1000 + 0
    10.1124/jpet.107.135681

    35. Tiftik, R.; Erol, A.; Cinar, M.; Kubat, H.; Ark, M.; Ulker, S.; Buyukafsar, K. Nitric oxide does not downregulate Rho-kinase (ROCK-2) expression in rat coronary endothelial cells. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 2008, 51, 140-147. 200 + 35

    Times Cited: 7
    2007
    34. Secilmis, M.; Ozue, O.; Emre, M.; Bueyuekafsar, K.; Kiroglu, O.; Ertug, P.; Karatas, Y.; Onder, S.; Singirik, E. Urocortin induces endothelium-dependent vasodilatation and hyperpolarization of rat mesenteric arteries by activating Ca2+-activated K+ channels. TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE, 2007, 213, 89-98. 0 + 20
    https://dx.doi.org/10.1620/tjem.213.89


    Times Cited: 4
    33. Turna, B.; Cinar, M.; Canda, A.; Orhan, E.; Tiftik, N.; Nazli, O.; Buyukafsar, K. Role of Rho-kinase in contractions of ureters from rabbits with unilateral ureteric obstruction. BJU INTERNATIONAL, 2007, 100, 1166-1171. 200 + 15
    https://dx.doi.org/10.1111/j.1464-410X.2007.07152.x


    Times Cited: 3
    32. Nacak, M.; Erbagci, Z.; Buyukafsar, K.; Yurtsever, A.; Tiftik, R. Association of angiotensin-converting enzyme gene insertion/deletion polymorphism with allergic contact dermatitis. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2007, 101, 101-103. 700 + 30
    https://dx.doi.org/10.1111/j.1742-7843.2007.00077.x


    Times Cited: 6
    2006
    31. Buyukafsar, K.; Yalcin, I.; Kurt, A.; Tiftik, R.; Seyhan, S.; Aksu, F. Rho-kinase inhibitor, Y-27632, has an antinociceptive effect in mice. EUROPEAN JOURNAL OF PHARMACOLOGY, 2006, 541, 49-52. 850 + 110
    https://dx.doi.org/10.1016/j.ejphar.2006.04.042


    Times Cited: 22
    30. Karatas, Y.; Secilmis, M.; Karayaylali, I.; Doran, F.; Singirik, E.; Buyukafsar, K.; Sagliker, Y.; Dikmen, A. Effect of tempol (4-hydroxy-tempo) on gentamicin-induced nephrotoxicity in rats. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 2006, 62, 167-167. 250 + 0
    29. Buyukafsar, K.; Akca, T.; Tiffik, R.; Sahan-Firat, S.; Aydin, S. Contribution of Rho-kinase in human gallbladder contractions. EUROPEAN JOURNAL OF PHARMACOLOGY, 2006, 540, 162-167. 900 + 45
    https://dx.doi.org/10.1016/j.ejphar.2006.04.028


    Times Cited: 9
    2005
    28. Seçilmiş, M.; Karataş, Y.; Yorulmaz, &.; Büyükafşar, K.; Şingirik, E.; Doran, F.; Inal, T.; Dikmen, A. Protective Effect of L-Arginine Intake on the Impaired Renal Vascular Responses in the Gentamicin-Treated Rats. S. KARGER AG, 2005, 100, 13-20. 450 + 0
    http://dx.doi.org/10.1159/000084657

    27. Sahan-Firat, S.; Tiftik, R.; Nacak, M.; Buyukafsar, K. Rho kinase expression and its central role in ovine gallbladder contractions elicited by a variety of excitatory stimuli. EUROPEAN JOURNAL OF PHARMACOLOGY, 2005, 528, 169-175. 650 + 35
    https://dx.doi.org/10.1016/j.ejphar.2005.10.055


    Times Cited: 7
    26. Koksel, O.; Yildirim, C.; Tiftik, R.; Kubat, H.; Tamer, L.; Cinel, L.; Kaplan, M.; Degirmenci, U.; Ozdulger, A.; Buyukafsar, K. Rho-kinase (ROCK-1 and ROCK-2) upregulation in oleic acid-induced lung injury and its restoration by Y-27632. EUROPEAN JOURNAL OF PHARMACOLOGY, 2005, 510, 135-142. 100 + 50
    https://dx.doi.org/10.1016/j.ejphar.2004.12.010


    Times Cited: 10
    2004
    25. LEVENT, A.; BÜYÜKAFŞAR, K. . BRITISH JOURNAL OF PHARMACOLOGY, 2004, 143, 431-437. 1000 + 0
    10.1038/sj.bjp.0705961

    24. Ark, M.; Ozveren, E.; Yazici, G.; Korkmaz, B.; Buyukafsar, K.; Arikan, O.; Kubat, H.; Songu-Mize, E. Effects of HA-1077 and Y-27632, two Rho-kinase inhibitors, in the human umbilical artery. CELL BIOCHEMISTRY AND BIOPHYSICS, 2004, 41, 331-342. 350 + 45
    https://dx.doi.org/10.1385/CBB:41:3:331


    Times Cited: 9
    23. Karatas, Y.; Secilmis, M.; Karayaylali, I.; Doran, F.; Buyukafsar, K.; Singirik, E.; Sagliker, Y.; Dikmen, A. Effect of tempol (4-hydroxy tempo) on gentamicin-induced nephrotoxicity in rats. FUNDAMENTAL & CLINICAL PHARMACOLOGY, 2004, 18, 79-83. 350 + 60
    https://dx.doi.org/10.1046/j.0767-3981.2003.00211.x


    Times Cited: 12
    22. Buyukafsar, K.; Arikan, O.; Ark, M.; Secilmis, A.; Un, I.; Singirik, E. Rho-kinase expression and its contribution to the control of perfusion pressure in the isolated rat mesenteric vascular bed. EUROPEAN JOURNAL OF PHARMACOLOGY, 2004, 485, 263-268. 850 + 70
    https://dx.doi.org/10.1016/j.ejphar.2003.11.076


    Times Cited: 14
    21. Levent, A.; Buyukafsar, K. Expression of Rho-kinase (ROCK-1 and ROCK-2) and its substantial role in the contractile activity of the sheep ureter. BRITISH JOURNAL OF PHARMACOLOGY, 2004, 143, 431-437. 1000 + 105
    https://dx.doi.org/10.1038/sj.bjp.0705961


    Times Cited: 21
    20. Buyukafsar, K.; Arikan, O.; Ark, M.; Kubat, H.; Ozveren, E. Upregulation of Rho-kinase (ROCK-2) expression and enhanced contraction to endothelin-1 in the mesenteric artery from lipopolysaccharide-treated rats. EUROPEAN JOURNAL OF PHARMACOLOGY, 2004, 498, 211-217. 900 + 50
    https://dx.doi.org/10.1016/j.ejphar.2004.07.092


    Times Cited: 10
    2003
    19. Buyukafsar, K.; Levent, A.; Un, I.; Ark, M.; Ankan, O.; Ozveren, E. Mediation of nitric oxide from photosensitive stores in the photorelaxation of the rabbit corpus cavernosum. EUROPEAN JOURNAL OF PHARMACOLOGY, 2003, 459, 263-267. 850 + 45
    https://dx.doi.org/10.1016/S0014-2999(02)02858-3


    Times Cited: 9
    18. Buyukafsar, K.; Levent, A. Involvement of Rho/Rho-kinase signalling in the contractile activity and acetylcholine release in the mouse gastric fundus. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2003, 303, 777-781. 1000 + 145
    https://dx.doi.org/10.1016/S0006-291X(03)00422-4


    Times Cited: 29
    17. Buyukafsar, K.; Un, I. Effects of the Rho-kinase inhibitors, Y-27632 and fasudil, on the corpus cavernosum from diabetic mice. EUROPEAN JOURNAL OF PHARMACOLOGY, 2003, 472, 235-238. 1000 + 165
    https://dx.doi.org/10.1016/S0014-2999(03)01905-8


    Times Cited: 33
    16. Dirlik, M.; Buyukafsar, K.; Cinel, I.; Cinel, L.; Caghkulekci, M.; Tamer, L.; Aydin, S.; Oral, U. Effect of ornithine on the ileal histology, nitric oxide production and lipid peroxidation in LPS-induced endotoxemia. ACTA MEDICA OKAYAMA, 2003, 57, 117-122. 650 + 0
    15. Buyukafsar, K.; Levent, A.; Ark, M. Expression of Rho-kinase and its functional role in the contractile activity of the mouse vas deferens. BRITISH JOURNAL OF PHARMACOLOGY, 2003, 140, 743-749. 1000 + 165
    https://dx.doi.org/10.1038/sj.bjp.0705479


    Times Cited: 33
    14. TİFTİK, E.; KIYKIM, A.; ALTINTAŞ, E.; DORUK, N.; SEZGİN, O.; Seyrek, E.; BÜYÜKAFŞAR, K.; Oral, U. . JOURNAL OF CLINICAL APHERESIS, 2003, 18, 132-133. 0 + 0
    2002
    13. YAZAR, A.; POLAT, G.; ÜN, İ.; LEVENT, A.; KAYGUSUZ, A.; BÜYÜKAFŞAR, K.; ÇAMDEVİREN, H. . ELSEVIER BV, 2002, 45, -. 300 + 0
    10.1006/phrs.2001.0944

    12. Cinel, I.; Buyukafsar, K.; Cinel, L.; Polat, A.; Atici, S.; Tamer, L.; Oral, U. The role of poly(ADP-ribose) synthetase inhibition in preventing endotoxemia-induced intestinal epithelial apoptosis. PHARMACOLOGICAL RESEARCH, 2002, 46, 119-127. 700 + 85
    https://dx.doi.org/10.1016/S1043-6618(02)00075-0


    Times Cited: 17
    11. Yazar, A.; Polat, G.; Un, I.; Levent, A.; Kaygusuz, A.; Camdeviren, H.; Buyukafsar, K. Effects of glibenclamide, metformin and insulin on the incidence and latency of death by oubain-induced arrhythmias in mice. PHARMACOLOGICAL RESEARCH, 2002, 45, 183-187. 200 + 15
    https://dx.doi.org/10.1006/phrs.2001.0944


    Times Cited: 3
    2001
    10. Ertug, P.; Buyukafsar, K.; Kumcu, E.; Gocmen, C.; Secilmis, A.; Singirik, E.; Dikmen, A.; Baysal, F. Effects of some divalent cations on nitrergic relaxations in the mouse corpus cavernosum. FUNDAMENTAL & CLINICAL PHARMACOLOGY, 2001, 15, 343-348. 650 + 5
    https://dx.doi.org/10.1046/j.1472-8206.2001.00045.x


    Times Cited: 1
    9. Buyukafsar, K.; Nelli, S.; Martin, W. Formation of nitric oxide from nitroxyl anion: role of quinones and ferricytochrome c. BRITISH JOURNAL OF PHARMACOLOGY, 2001, 132, 165-172. 1000 + 50
    https://dx.doi.org/10.1038/sj.bjp.0703812


    Times Cited: 10
    8. BÜYÜKAFŞAR, K.; YAZAR, A.; DÜŞMEZ APA, D.; ÖZTÜRK, A.; POLAT, G.; LEVENT, A. . PHARMACOLOGICAL RESEARCH, 2001, 44, 321-328. 850 + 0
    10.1006/phrs.2001.0864

    7. ERTUĞ, F.; BÜYÜKAFŞAR, K.; KUMCU, E.; GÖÇMEN, C.; SEÇİLMİŞ, M.; ŞİNGİRİK, E.; DİKMEN, A.; BAYSAL, F. . WILEY, 2001, 15, -. 650 + 0
    10.1046/j.1472-8206.2001.00045.x

    6. Buyukafsar, K.; Yazar, A.; Dusmez, D.; Ozturk, H.; Polat, G.; Levent, A. Effect of trapidil, an antiplatelet and vasodilator agent on gentamicin-induced nephrotoxicity in rats. PHARMACOLOGICAL RESEARCH, 2001, 44, 321-328. 850 + 80
    https://dx.doi.org/10.1006/phrs.2001.0864


    Times Cited: 16
    5. BÜYÜKAFŞAR, K. . JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2001, 26, 15-21. 1000 + 0
    10.1016/S0731-7085(01)00392-2

    2000
    4. Nelli, S.; Hillen, M.; Buyukafsar, K.; Martin, W. Oxidation of nitroxyl anion to nitric oxide by copper ions. BRITISH JOURNAL OF PHARMACOLOGY, 2000, 131, 356-362. 750 + 160
    https://dx.doi.org/10.1038/sj.bjp.0703550


    Times Cited: 32
    1999
    3. Buyukafsar, K.; Gocmen, C.; Secilmis, A.; Karatas, Y.; Gokturk, S.; Kalyoncu, N. Evidence that the nitrergic neurotransmitter and endothelium-derived relaxing factor might be S-nitrosothiols in the mouse corpus cavernosum. ACTA MEDICA OKAYAMA, 1999, 53, 209-215. 850 + 25

    Times Cited: 5
    2. Buyukafsar, K.; Demirel-Yilmaz, E.; Gocmen, C.; Dikmen, A. Depletion and restoration of the putative photosensitive materials store yielding nitric oxide in the isolated mouse gastric fundus. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 1999, 290, 768-773. 950 + 60

    Times Cited: 12
    1996
    1. Ogulener, N.; Yaktubay, N.; Buyukafsar, K.; Dikmen, A.; Baysal, F. Some properties of the photorelaxation induced by UV light and possible contribution of nitric oxide in the isolated mouse gastric fundal smooth muscle. ASIA PACIFIC JOURNAL OF PHARMACOLOGY, 1996, 11, 109-120. 700 + 50

    Times Cited: 10
    International - Covered by Other International Indexes 100
    2013
    1. Kurt, A.; Tiftik, R.; Ün, İ.; Ülker, S.; Büyükafşar, K. G protein-coupled estrogen receptor1 (GPER 1) may mediate Rho-kinase (RO CK-2) up-regulation in coronary endothelial cells. ENDOCRINE REGULATIONS, 2013, 47, 75-84. 100 + 0
    10.4149/endo_2013_02_75

    International - Other 100
    2020
    1. BÜYÜKAFŞAR, K. . DUZCE TIP FAKULTESI DERGISI, 2020, 22, 71-78. 100 + 0
    10.18678/dtfd.777234

    National - Covered by ULAKBIM 820
    2023
    6. AL HENNAWİ, K.; TİFTİK, R.; ÜN, İ.; BÜYÜKAFŞAR, K. . DICLE MEDICAL JOURNAL/DICLE TIP DERGISI, 2023, 50, 327-334. 130 + 0
    10.5798/dicletip.1360653

    2019
    5. ÇARÇAK YILMAZ, N.; Melis, Y.; ERYİĞİT, T.; KURT, A.; URHAN KÜÇÜK, M.; ONAT, F.; BÜYÜKAFŞAR, K. . JOURNAL OF THE TURKISH EPILEPSI SOCIETY, 2019, 25, 1-7. 40 + 0
    10.14744/epilepsi.2018.30592

    4. Yurtsever, A.; BÜYÜKAFŞAR, K. . MERSIN UNIVERSITESI SAGLIK BILIMLERI DERGISI, 2019, 12, 257-270. 200 + 0
    10.26559/mersinsbd.538541

    2018
    3. TELLİ, G.; TEL, B.; BÜYÜKAFŞAR, K.; GÜMÜŞEL, B. . JOURNAL OF RESEARCH IN PHARMACY, 2018, 22, 95-101. 150 + 0
    10.12991/jrp.2018.82

    2017
    2. Büyükafşar, K. Techniques about writing a scientific article in health sciences. MERSIN UNIVERSITESI SAGLIK BILIMLERI ENSTITUSU DERGISI, 2017, 10, 252-269. 200 + 0
    1. Nayir, E.; Cor, S.; Mert Altintas, Z.; Buyukafsar, K.; Tiftik, R.; Ata, A.; Arıcan, A. Comparative investigation of antitumoral effectiveness of Rho-kinase inhibitor Y-27632, pravastatin and atorvastatin in anaplastic thyroid cancer cell culture. JOURNAL OF ONCOLOGICAL SCIENCES, 2017, 3, 62-65. 100 + 0
    10.1016/j.jons.2017.05.005

    International - Scientific Book (Excluded Thesis) 0
    1. BÜYÜKAFŞAR, K. Ouick Updates of Botulinum Toxin in Dermatology for Non-Cosmetic Purposes, ISBN: 978-88-947285-0-7, World Health Academy Publishing House, Number of print: 1, Total Printing Number: , 138 Page, English, Montecatini-Terme (PT), Italy, 2022. 0
    National - Chaper(s) in Book (Translated) 100
    1. BÜYÜKAFŞAR, K.; ÜN, İ.; TİFTİK, R.; YURTSEVER, A. BİR BAKIŞTA FARMAKOLOJİ, ISBN: 978-625-7275-79-8, Akademisyen Kitabevi A.Ş., Number of print: 1, Total Printing Number: , 119 Page, Turkish, ANKARA, Turkey, 2021. 0
    2. Büyükafşar, K. The Basis of Pharmacology and Therapeutics, ISBN: 0-07-142280-3, NOBEL TIP, Number of print: 1, Total Printing Number: 1000, 18 Page, Turkish, İstanbul, Turkey, 2009. 50
    3. Büyükafşar, K. Goodman & Gilman Pharmacology, ISBN: 978-975-277-676-0, Ayrıntı Basım ve Yayın Matbaacılık, Number of print: 2, Total Printing Number: 1000, 1205 Page, Turkish, Ankara, Turkey, 2017. 50
    National - Scientific Book (Excluded Thesis) 100
    1. BÜYÜKAFŞAR, K. Hızlı Güncel: İvermektinin Dermatolojide Kullanımı, ISBN: 978-605-72379-7-2, Kongre Kitabevi, Number of print: 1, Total Printing Number: , 102 Page, Turkish, Ankara, Turkey, 2023. 0
    2. BÜYÜKAFŞAR, K. Jak İnhibitörlerinin Dermatolojide Güncel Kullanımı, ISBN: 78-605-80175-2-, Kongre Kitabevi, Number of print: 1, Total Printing Number: , 163 Page, Turkish, Ankara, Turkey, 2024. 0

    International - Full text - Oral 700

    4. KILIÇDAĞI, A.; YALÇINKAYA, F.; BAYRAKTAR, D.; YURTSEVER, A.; BÜYÜKAFŞAR, K., DİYET KÖKENLİ ESTROJENİK MADDELER İLE BUNLARIN ADİPOJENİK ETKİLERİNDE GPER-1 RESEPTÖRÜNÜN OLASI ROLÜ. VII. INTERNATIONAL HALICH CONGRESS ON MULTIDISCIPLINARY SCIENTIFIC RESEARCH, 2024-01-23, 2024-02-25, İstanbul, Turkey, . 100

    3. YURTSEVER, A.; BÜYÜKAFŞAR, K., TROMBİN, LİZOFOSFATİDİK ASİT VE C3 EKZOENZİMİN 3T3-L1 PREADİPOSİTLERİNDE RHOA AKTİVASYONU ÜZERİNE ETKİSİ. 3. International Mediterranean Symposium, 2019-10-29, 2019-11-02, mersin, Turkey, . 200

    2. YURTSEVER, A.; BÜYÜKAFŞAR, K., 3T3-L1 Preadipositlerde Bakteriyel Lipopolisakkaridin LIM-kinaz Aktivitesi Üzerine Etkisi. 6. ULUSLARARASI MULTİDİSİPLİNER ÇALIŞMALARI KONGRESİ, 2019-04-26, 2019-04-27, gaziantep, Turkey, . 200

    1. BÜYÜKAFŞAR, K., Mitochondrial Theory of Aging. INDERCOS-2018, 2018-03-15, 2018-03-17, , , . 200

    International - Full text - Davetli 0

    7. BÜYÜKAFŞAR, K., Mas-Related G Protein-coupled Receptor X2 (MRGPRX2) and Allergy. 6th International Dermatology and Cosmetology Congress, 2021-03-11, 2021-03-14, , , . 0

    6. BÜYÜKAFŞAR, K., Mast cell secratory drugs and foods. INDERCOS5, 2020-03-12, 2020-03-15, , , . 0

    5. BÜYÜKAFŞAR, K., Stress and aging. INDERCOS5, 2020-03-12, 2020-03-15, , , . 0

    4. BÜYÜKAFŞAR, K., Sleeping beauty: Is it anti-aging?. INDERCOS5, 2020-03-12, 2020-03-15, , , . 0

    3. BÜYÜKAFŞAR, K., Kök Hücre Bir İlaç mıdır?. MEDPHACON-2019, 2019-04-26, 2019-04-28, , , . 0

    2. BÜYÜKAFŞAR, K., Pharmacological profile of botulinum toxins. INDERCOS4, 2019-03-27, 2019-03-30, , , . 0

    1. BÜYÜKAFŞAR, K., Telomerase activators for antiaging. INDERCOS4, 2019-03-27, 2019-03-30, , , . 0

    International - Abstract - Oral 190

    2. BAZZAZ, M.; KOÇ, S.; BÜYÜKAFŞAR, K., SIÇAN ARKA BACAK DAMAR YATAĞINDAN MOTOR SİNİR UYARIMI İLE SALIVERİLEN NÖROPEPTİD DÜZEYLERİNİN ÖLÇÜMÜ. VII. INTERNATIONAL HALICH CONGRESS ON MULTIDISCIPLINARY SCIENTIFIC RESEARCH, 2024-01-23, 2024-01-25, İstanbul, Turkey, 2024. 100
    Scientific_Meetings_002.pdf

    1. BÜYÜKAFŞAR, K.; ONSOZ, E.; BAHAR, L.; ARSLAN, B.; AYAR, G., Possible Regenerative Effect of Bone Marrow Mesenchymal Stem Cell-Derived Exosomes in Oleic Acid-Induced Lung Injury in Rats. INTERNATIONAL CONFERENCE ON GLOBAL PRACTICE OF MULTIDISCIPLINARY SCIENTIFIC STUDIES-IV, 2023-04-28, 2023-04-30, girne, TRNC, 2023. 90
    Scientific_Meetings_001.pdf

    International - Abstract - Poster 30

    1. ÇARÇAK YILMAZ, N.; Yavuz, M.; KARAMAHMUTOĞLU, T.; BÜYÜKAFŞAR, K.; ONAT, F., Effect of rho-kinase inhibitor Y-27632 on absence seizures in genetic absence epilepsy rats from Strasbourg. 32nd International Epilepsy Congress, 2017-09-02, 2017-09-06, , , . 30

    National - bilimsel-toplantilar.icerikTurleri. - Oral 0

    1. YAVUZ, M.; ÇARÇAK YILMAZ, N.; KURT, A.; BÜYÜKAFŞAR, K.; ONAT, F., Rho-kinaz Enzim Inhibitörü Fasudil’xxin Absans Epilepsili Sıçanlarda Nöbetlere Etkisi. 15th National Neuroscience Congress, Sakarya, 2017-05-07, 2017-05-10, , Turkey, . 0

    National - Full text - Oral 90

    1. BÜYÜKAFŞAR, K.; TİFTİK, R.; SEÇİLMİŞ, M.; İLHAN, E.; Alzayed, Z., Expression of Rho and Rho-kinase Proteins in the Muscular and Vascular Tissues of the Rat Hind Limb . 6.Uluslararası Multidisiplinler Çalışma Kongresi, 2019-04-26, , Gaziantep, Turkey, . 90

    National - Full text - Davetli 0

    4. BÜYÜKAFŞAR, K., Mezenkimal Kök Hücre Bir İlaç mıdır?. Kök Hücre ve Rejeneratif Tıp Sempozyumu, 2018-09-07, 2018-09-08, , Turkey, . 0

    3. BÜYÜKAFŞAR, K., Mezenkimal Kök Hücre Bir İlaç mıdır?. Kök Hücre ve Rejeneratif Tıp Sempozyumu, 2018-09-07, 2018-09-08, Mersin, Turkey, 2018. 0
    http://www.tfd.org.tr/node/487/

    2. BÜYÜKAFŞAR, K., Mezenkimal Kök Hücre Bir İlaç mıdır?. Kök Hücre ve Rejeneratif Tıp Sempozyumu, 2018-09-07, 2018-09-08, , Turkey, . 0

    1. BÜYÜKAFŞAR, K., Projenin amaç, hedef ve özgün değerinin yazılması. Temel ve Translasyonel Araştırma Projesi Yazma ve Proje Desteklerine Başvuru Eğitimi, 2017-11-30, 2017-12-01, , Turkey, . 0

    National - Abstract - Oral 30

    1. Yavuz, M.; ÇARÇAK YILMAZ, N.; KURT, A.; BÜYÜKAFŞAR, K.; ONAT, F., Rho-kinaz enzim inhibitörü Fasudil’in absans epilepsili sıçanlarda nöbetlere etkisi. 15. Ulusal Sinirbilim Kongresi, 2017-05-07, 2017-05-10, Sakarya, Turkey, . 30

    National - Abstract - Davetli 0

    1. BÜYÜKAFŞAR, K., Kalp-dmar sistemde Rho/Rho-kinaz yolağı. Vasküler ve Moleküler Kardiyoloji Derneği 2017 Çalıştayı, 2017-11-04, 2017-11-05, , Turkey, . 0

    International - Manager 0

    1. , projects.kurumlar.29, Project Number: , EUR, Manager, 2020,Completed. 0

    National - Manager 1600

    17. Investigation of the Irisin-Mediated Effect of Electrical Muscle Stimulation and Swimming Exercise in the Rat Pulmonary Arterial Hypertension Model, BAP, Project Number: 2024-TP3-5062, 90000 TL, Manager, Continue... 100

    16. , BAP, Project Number: , 20000 TL, Manager, Continue... 100

    15. THE POSSIBLE ROLE OF THE GPER-1 RECEPTOR IN THE DIET-ORIENTED ESTROGENIC SUBTANCES AND ADIPOGENIC EFFECTS, BAP, Project Number: 2022-1-TP2-4703, 15000 TL, Manager, Continue... 100

    14. Possible Regenerative Effect of Bone Marrow Mesenchymal Stem Cell-Derived Exosomes in Oleic Acid-Induced Lung Injury in Rats, BAP, Project Number: 2021-2-TP2-4522, 11250 TL, Manager, Continue... 100

    13. Sıçan Arka Bacak Damar Yatağı Perfüzyon Basıncının Kontrolüne Rho/Rho-kinaz Yolağının Katkısı, BAP, Project Number: 2018-2-AP3-2938, 20000 TL, Manager, Continue... 100

    12. Possible Role of Rock Inhibition in the Vasodilator Effect of Omentin on the Aorta, Renal and Superior Mesenteric Arteries, BAP, Project Number: 2024-TP2-5073, 60000 TL, Manager, Continue... 100

    11. The contribution of Rho/Rho-kinase pathway on the control of perfusion pressure in the rat isolated perfused hind limb vascular bed , BAP, Project Number: 2018-2-AP3-2938, 20000 TL, Manager, Continue... 100

    10. , BAP, Project Number: , 20000 TL, Manager, 2021,Completed. 100

    9. POSSIBLE ROLE OF RHO/RHO-KINASE SIGNALLING IN PATHOPHYSILOGY OF ABSENCE EPILEPSY, TÜBİTAK, Project Number: 113S221, 236 TL, Manager, 2016,Completed. 100
    http://www.tubitak.gov.tr

    8. , TÜBİTAK, Project Number: , 236700 TL, Manager, 2016,Completed. 100

    7. , projects.kurumlar.20, Project Number: , EUR, Manager, 2015,Completed. 0

    6. Effects of nitric oxide on proliferation, differantiation and organisation of actin cytoskeleton in preadipocytes (3T3-L1): Possible role of Rho/Rho-kinase pathway, TÜBİTAK, Project Number: 110S451, 245500 TL, Manager, 2014,Completed. 100
    http://www.tubitak.gov.tr

    5. , BAP, Project Number: , 12826 TL, Manager, 2011,Completed. 100

    4. Effects of estrogen and progesterone on differantiation and adipcytokine release in preadipocytes (3t3-L1): Possible role of Rho/Rho-kinase pathway, TÜBİTAK, Project Number: 109S126, 114100 TL, Manager, 2011,Completed. 100
    http://www.tubitak.gov.tr

    3. Investigation of Rho-kinase upregulation by 17b-estradiol in rat coronary endothelial cells, TÜBİTAK, Project Number: 108S421, 5600 TL, Manager, 2010,Completed. 100
    http://www.tubitak.gov.tr

    2. , BAP, Project Number: , 10000 TL, Manager, 2009,Completed. 100

    1. , BAP, Project Number: , 33000 TL, Manager, 2006,Completed. 100

    National - Researcher 150

    3. Examination of the Anticancer Impact of Recently Synthesized Palladium Conjugated Schiff Base Metal Complexes on Mouse Embryonic Fibroblast Cell Line and Non-Small Cell Lung Cancer Cell Line, BAP, Project Number: 2023-1-AP1-4896, 60000 TL, Researcher, Continue... 50

    2. Investigation of ROCK1 (G / T), ROCK2 (A / C) and RhoA (A / T) Gene Polymorphisms and Expressions in Cholesteatoma Patients, BAP, Project Number: 2017-2-AP4-2592, 30000 TL, Researcher, 2018,Completed. 50

    1. , BAP, Project Number: , 5000 TL, Researcher, 2008,Completed. 50

    National - projects.gorevler. 0

    1. , BAP, Project Number: , 30000 TL, projects.gorevler., 2008,Completed. 0

    Supervised Master Theses 950

    5. Akif Hakan Kurt, Effects of on sex hormons onRho/Rho-kinase pathway in coronary vascular endothelial cells , Others, Mersin University, Continue. 200

    4. Rukiye Nalan Tiftik, Possible relationship between nitric oxide (NO) and Rho/Rho-kinase pathway in rat coronary microvascular endothelial cells, Graduate School of Health Sciences, Mersin University, Completed. 200

    3. Onur Arıkan, Rho-kinase expression and effects of its inhibitors in the control of perfusion pressure in rat mesenteric vascular bed, Graduate School of Health Sciences, Mersin University, Completed. 200

    2. Caner Kaplan, Nature of the relaxation induced by ultraviolet light in the rabbit corpus cavernosum, Graduate School of Natural and Applied Sciences, Mersin University, Completed. 150
    http://mersin.edu.tr

    1. Özge Güldalı Dutlu, Effects of cytidine 5' triphosphate on the reactivity of urogenital, gastrointestinal and respiratory smooth muscles, Graduate School of Health Sciences, Mersin University, Completed. 200

    Supervised Expertise in Medicine Theses 1200

    3. Havva Kubat, Rho/Rho-kinase pathway in the brain, corpus cavernosum and aorta of alcoholic mice, Others, Mersin University, Completed. 400

    2. İsmail Ün, Investigation of Rho/Rho-kinase signalling in the aorta, corpus cavernosum and gastric fundus from diabetic mice, Others, Mersin University, Completed. 400

    1. Mehtap Pektaş, Effects of estrogens and progesteron on adipocytokines release and differentiation in preadipocytes (3T3-L1): Possible contribution of Rho/Rho-kinase pathway, Others, Mersin University, Completed. 400

    Supervised Doctorate Theses 1200

    3. Ahmet Sencer Yurtsever, Effects of nitric oxide on the proliferation, differentiation and actin cytoskeleton organisation in preadipcytes (3T3-L1): Possible role of Rho/Rho-kinase pathway, Graduate School of Health Sciences, Mersin University, Continue. 400

    2. Rukiye Nalan Tifitik, Functional importance of Rho/Rho-kinase signalling pathway in human erythrocytes, Graduate School of Health Sciences, Mersin University, Completed. 400

    1. Akif Hakan Kurt, Role of G-protein-coupled estrogen receptor (GPER) on the control of perfusion pressure in the rat kidney, Others, Mersin University, Completed. 400

    International Journal [Year, Count] 39
    1. ARAB JOURNAL OF GASTROENETEROLOGY , [ 2017 : 1 ] . 5
    2. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY , [ 2016 : 1 ] . 5
    3. CELL BIOCHEMISTRY AND BIOPHYSICS , [ 2015 : 1 ] . 5
    4. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY , [ 2015 : 1 ] . 5
    5. RENAL FAILURE , [ 2015 : 1 ] . 5
    6. TURKISH JOURNAL OF HEMATOLOGY , [ 2015 : 1 ] . 4
    7. HTTP://WWW.BIOMED.CAS.CZ/PHYSIOLRES/ , [ 2018 : 1 ] . 5
    8. HTTPS://JOURNALS.LWW.COM/CARDIOVASCULARPHARM/PAGES/DEFAULT.ASPX , [ 2018 : 1 ] . 5
    National Journal [Year, Count] 1
    1. ANATHOLIAN JOURNAL OF CARDIOLOGY , [ 2018 : 1 ] . 1

    International
    1. Glasgow University , 2000-01-24 - 2000-05-24, Glasgow, England / United Kingdom.

    International
    1. Glasgow University Institute of Life Science and Biomedical Research , 2000-01-01 - 2000-05-01, Glasgow, England / United Kingdom.
    2. Gent University , 1994-02-01 - 1994-03-26, Gent, Belgium.

    National 1200
    1. , 2001-04-14, Ankara, Turkey. 50
    2. , 2002-06-07, Ankara, Turkey. 1000
    3. , 2003-09-01, Ankara, Turkey. 50
    4. , 2005-04-14, Ankara, Turkey. 50
    5. , 2009-04-14, Ankara, Turkey. 50

    1. Turkish Pharmacology Asscociation , Member No: 254, Turkey, 1992-01-01-Continue.
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