Kök Hücre ve Rejeneratif Tıp Anabilim Dalı

MİSYON VE VİZYON
“Mersin Üniversitesi Kök Hücre ve Rejeneratif Tıp Anabilim Dalı, Doku ve Hücre Üretim uygulamaları ile kök ve öncül hücrelerle ilgili konuların daha iyi anlaşılabilmesi ve kök hücrenin sıradışı potansiyelinden yararlanılması yönünde, ulusal ve uluslararası düzeylerde araştırma (deneysel ve klinik çalışmalar, temel bilimler, doku mühendisliği,), üretim (klinik standartlarda hücre ve hücre ürünleri), eğitim ve danışmanlık faaliyetlerinin sürdürülmesini ve insan hastalıklarının tedavisinde ileri düzeyde yenileyici tıp yöntemlerinin hekimlik ve etik değerler gözetilerek uygulanması için zemin hazırlanmasını ve konuya ilişkin ulusal ve uluslararası mevzuat çerçevesinde gerek görülen her türlü hizmeti gerçekleştirmeyi ilke edinmiştir. Kök hücre nakillerinde ve kök hücre araştırmalarında bölgesel güç olmayı amaçlayanMersin Üniversitesi Kök Hücre ve Rejeneratif Tıp Anabilim Dalı, kök hücre çalışmalarının genetik bozukluklar, kanser tedavileri ve kan hastalıklarının yanı sıra nöroloji, kardiyoloji, ortopedi, endokrinoloji, dermatoloji, plastik ve rekonstrüktif cerrahi, farmakogenetik, biyoteknolojik çalışmalar gibi pek çok bilim dalını ilgilendiren konularda etkin ve lider olmak temel hedefidir. İnsan kaynaklı hücrelerin üretiminde; İyi Üretim Koşulları (GMP) ve İyi Laboratuvar Koşulları (GLP) ile “biyoteknolojik ilaç ve yöntemlerin” geliştirilmesi hedeflenmektedir.
Son İki Yılda Uluslararası Dergilerde Yayınlanan Makaleler
2024
33. Yaman, S.; Demir karakuş, D.; Karagülle, N. Design of gelatin cryogel scaffolds with the ability to release simvastatin for potential bone tissue engineering applications. BIOMEDICAL MATERIALS, 2024, 19, 1-15.
10.1088/1748-605X/ad651e
32. Eras, N.; Tuncel daloğlu, F.; Altıntaş, Z.; Erden ertürk, S. Clinicopathological characteristics and BRCA1/BRCA2 pathogenic variants of patients with breast cancer. POLISH JOURNAL OF PATHOLOGY, 2024, 75, 1-7.
10.5114/pjp.2024.135703
31. Ayaz, F.; Demir karakuş, D.; Karagülle, N. Electrospun nanofiber mats caged the mammalian macrophages on their surfaces and prevented their inflammatory responses independent of the fiber diameter. SCIENTIFIC REPORTS, 2024, 14, 1-8.
10.1038/s41598-024-61450-3
30. Demir karakuş, D.; Ceylan, S.; Karagülle, N. Chitosan based injectable cryospheres as a potential biopolymeric carrier for drug delivery systems: Characterization, biocompatibility and drug release. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2024, 102, 1-9.
10.1016/j.jddst.2024.106406
29. Alabaş, E.; özçimen, A. The Supression of Migration and Metastasis via Inhibition of Vascular Endothelial Growth Factor in Pancreatic Adenocarcinoma Cells Applied Danusertib. TURKISH JOURNAL OF GASTROENTEROLOGY, 2024, 35, 150-157.
10.5152/tjg.2024.22319
28. Demirbağ, B.; Büyükafşar, K.; Kaya, H.; Yıldırım, M.; Bucak, .; ünver, H.; Erdoğan, S. Investigation of the anticancer effect of newly synthesized palladium conjugate Schiff base metal complexes on non-small cell lung cancer cell line and mouse embryonic fibroblast cell line. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2024, 735, 150658-.
10.1016/j.bbrc.2024.150658
27. öksüz, N. Reliability and Validity Study of the Migraine Interictal Burden Scale-4 in Turkish. NEUROLOGICAL SCIENCES AND NEUROPHYSIOLOGY, 2024, 41, 153-161.
10.4103/nsn.nsn_159_23
26. Doğan, H.; özçimen, A.; Silici, S. Interaction of olive oil-based propolis and caffeic acid phenethyl ester with methylprednisolone used in the treatment of human acute myeloid leukemia. MOLECULAR BIOLOGY REPORTS, 2024, 51, 551-559.
10.1007/s11033-024-09493-7
25. öksüz gürlen, N.; Güler aksu, G.; özdemir, A.; özge, A. Internalizing disorders rather than ADHD are risk factors for chronicity in pediatric migraine patients. TURKISH JOURNAL OF MEDICAL SCIENCES, 2024, 54, 930-937.
10.55730/1300-0144.5870
24. öksüz gürlen, N.; Ghouri, R.; Taşdelen, B.; Uludüz, D.; özge, A. Mild Cognitive Impairment Progression and Alzheimer’s Disease Risk: A Comprehensive Analysis of 3553 Cases over 203 Months. JOURNAL OF CLINICAL MEDICINE, 2024, 13, -.
10.3390/jcm13020518
23. Temiz reşitoğlu, M.; Tiftik, R. mTORC2 inhibition by JR-AB2-011 improves IL-1β-induced inflammation, catabolic response, and apoptosis in human chondrocytes through IκB-α/NF-κB p65. CELLULAR AND MOLECULAR BIOLOGY, 2024, 70, -.
10.14715/cmb/2024.70.9.5
22. Demirbağ, B.; Büyükafşar, K.; Yıldırım, M.; Bucak, .; ünver, H.; Erdoğan, S. Investigation of the anticancer effect of newly synthesized palladium conjugate Schiff base metal complexes on non-small cell lung cancer cell line and mouse embryonic fibroblast cell line. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2024, 735, -.
10.1016/j.bbrc.2024.150658
21. Demirbağ, B.; Ballı, E.; Yıldırım, M.; ünver, H.; Temel, G.; Yılmaz, M.; Değirmenci, E.; Kibar, D. Investigation of the anticancer of photodynamic therapy effects by using the novel Schiff base ligand palladium complexes on human breast cancer cell line. CHEMICAL PAPERS, 2024, 78, -.
10.1007/s11696-024-03622-z
20. Demirbağ, B. Investigatio n of th e anticancer effect of newl y synthesize d palladiu m conjugat e Schiff base meta l complexe s on no n -smal l cell lung cancer cell line an d mous e embryoni c fibroblast cell line. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2024, , -.
2023
19. Eras, N. Contribution of genotypes in Prothrombin and Factor V Leiden to COVID-19 and disease severity in patients at high risk for hereditary thrombophilia. JOURNAL OF MEDICAL VIROLOGY, 2023, e28469, 0-0.
10.1002/jmv.28457
18. çevik, .; çevik, K.; Temel, G.; şahin, L. Maternal separation increased memory function and anxiety without effects of environmental enrichment in male rats. ELSEVIER BV, 2023, 166, 1-10.
10.1016/j.bbr.2022.114280
17. Müsüroğlu, S.; şahin, L.; Kocahan, S.; Annaç, E.; Tıraşçı, N. Effect of caffeine on hippocampal memory and levels of gene expression in social isolation stress. WILEY, 2023, 83, 1-12.
10.1002/jdn.10292
16. özge, A.; Ghouri, R.; öksüz gürlen, N.; Taşdelen, B. Early intervention and adding effective doses of EGb761 like Ginkgo extract slow down dementia progression: insights to the neurovascular unit. FRONTIERS MEDIA SA, 2023, 14, 1-18.
10.3389/fneur.2023.1240655
15. Demir karakuş, D.; Karagülle, N.; Vaseashta, A. Electrospun Nanofibers for Biomedical, Sensing, and Energy Harvesting Functions. POLYMERS, 2023, 15, 1-18.
10.3390/polym15214253
14. şahin, L.; Müsüroğlu, S.; çevik, .; çevik, K.; Temel, G. Hyperthyroidism leads learning and memory impairment possibly via GRIN2B expression alterations. ELSEVIER BV, 2023, 6, 1-7.
10.1016/j.brainres.2022.148209
13. Mohsenzadeh, E.; Demir karakuş, D.; Ceylan, S.; Khenoussi, N.; Schacher, L.; Adolphe, D.; Karagülle, N. A bi-layer electrospun polyurethane/silicone membrane scaffold: drug delivery and cytotoxicity studies. BULLETIN OF MATERIALS SCIENCE, 2023, 46, 1-8.
10.1007/s12034-023-02975-7
12. özge, A.; Ghouri, R.; öksüz gürlen, N.; Taşdelen, B. Predictive factors for Alzheimer’s disease progression: a comprehensive retrospective analysis of 3,553 cases with 211 months follow-up. FRONTIERS MEDIA SA, 2023, 14, 1239995-1239995.
10.3389/fneur.2023.1239995
11. Ghouri, R.; öksüz gürlen, N.; Taşdelen, B.; özge, A. Factors affecting progression of non-Alzheimer dementia: a retrospective analysis with long-term follow-up. FRONTIERS MEDIA SA, 2023, 14, 1240093-1240093.
10.3389/fneur.2023.1240093
10. Arslan, B.; Baltacı, S.; Bayyurt, B.; özbilüm şahin, N.; Akyürek, M.; Bakır, M.; Arslan, S. RNA N6-Methyladenosine Pathway Writer Genes Expression Levels and Clinical Severity of Infection in Covid-19 Patients. ALLERTON PRESS, 2023, 38, 129-136.
10.3103/S0891416823020118
9. Bahar, M.; Demirci, N.; Bahar, L.; şahin, L. The effect of swimming and running exercises on oxidant-antioxidant and lipid profiles in streptozotocin-induced diabetic rats. HIPPOKRATIA, 2023, 27, 148-154.
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8. öksüz gürlen, N.; özge, A. Gray zones in the trigeminal autonomic cephalalgias. NEUROLOGICAL SCIENCES AND NEUROPHYSIOLOGY, 2023, 40, 15-19.
10.4103/nsn_108_22
7. öksüz, N. Real-life experiences with galcanezumab and predictors for treatment response in Turkey. SPRINGER SCIENCE AND BUSINESS MEDIA LLC, 2023, 23, 418-418.
10.1186/s12883-023-03467-1
6. öksüz, N. One Patient, Three Providers: A Multidisciplinary Approach to Managing Common Neuropsychiatric Cases. MDPI AG, 2023, 12, 5754-5754.
10.3390/jcm12175754
5. öksüz gürlen, N.; Kömür, M.; Doğu, O. Treatment Dilemma in a Juvenile Huntington’s patient presenting with psychiatric symptoms. NÖROPSIKIYATRI ARŞIVI, 2023, 60, 87-89.
10.29399/npa.28058
4. Hydzik, P.; Francik, R.; Francik, S.; Gomółka, E.; Derici eker, E.; Krośniak, M.; Noga, M.; Jurowski, K. The Critical Assessment of Oxidative Stress Parameters as Potential Biomarkers of Carbon Monoxide Poisoning. INT J MOL SCI, 2023, 24, -.
10.3390/ijms241310784
3. Arslan, B.; Baltacı, S.; Tüzemen bayyurt, E.; özbilüm şahin, N.; Eser akyürek, M.; Bakır, M.; Arslan, S. RNA N6-Methyladenosine Pathway Writer Genes Expression Levels and Clinical Severity of Infection in Covid-19 Patients. ALLERTON PRESS, 2023, 38, -.
10.3103/S0891416823020118
2. Demirbağ, B. Protective effect of paricalcitol in rat testicular damage induced by subchronic 1800 MHz radiofrequency radiation. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2023, 680, -.
10.1016/j.bbrc.2023.09.024
1. Eras, N. Contribution of genotypes in Prothrombin and Factor V Leiden to COVID‐19 and disease severity in patients at high risk for hereditary thrombophilia. JOURNAL OF MEDICAL VIROLOGY, 2023, 95, -.
10.1002/jmv.28457